Autism

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The effectiveness of hyperbaric oxygen therapy in children and adolescents and with autism spectrum disorders: A systematic review and meta-analysis

Brief Synopsis:  "A total of 17 studies with 890 patients were ultimately included in the meta-analysis. The meta-analysis revealed moderately large, significant effects of hyperbaric oxygen therapy, reducing core symptoms of autism [SMD = −0.66, 95 % CI (−1.04, −0.28), P = 0.0006], and improving three aspects of daily performances (communication [SMD = −0.88, 95 % CI (−1.71,-0.04), P = 0.04], cognitive awareness [SMD = −0.93, 95 % CI (−1.51, −0.35), P = 0.002], and behavior [SMD = −0.80, 95 % CI (− 1.46, −0.13), P = 0.02] in children and adolescents with autism." 

 Hyperbaric Oxygen Therapy Alleviates Social Behavior Dysfunction and Neuroinflammation in a Mouse Model for Autism Spectrum Disorders - PubMed 

Brief Synopsis:  "Together, our research suggests that HBOT has the potential to improve the clinical outcome of ASD by ameliorating some of the core pathophysiological processes responsible for the development of the disorder. "

 View of Biomolecular Mechanism Of Hyperbaric Oxygen Therapy As An Alternative Treatment In Autism Spectrum Disorder 

Brief Synopsis:  "Frye et  al. (2021) highlight that by enhancing brain perfusion,  HBOT may relieve ASD-related symptoms such as language   difficulties,   repetitive   behaviors, emotional  disturbances,  and  impaired  facial expressions.  Additionally,  HBOT  has  anti-inflammatory  properties  that  may  benefit individuals   with   ASD   who   experience neuroinflammation,  immune  irregularities,  and gastrointestinal  issues  (Zarimeidani,  2025)."